PDpep1.3

PDpep1.3 is a peptide inhibitor targeting ?-synuclein, which disrupts the direct interaction between ?-synuclein and CHarged Multivesicular body Protein 2B (CHMP2B) . This disruption enables PDpep1.3 to restore the degradative functions of endosomes and lysosomes, reducing the levels and aggregation of ?-synuclein, and safeguarding dopaminergic neurons from ?-synuclein-induced degeneration. PDpep1.3 is useful for research on neurodegenerative diseases and protein-protein interactions.

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