Ardeemin
Product Specifications
CAS Number
148441-25-2
Target
P-gp
Related Pathways
Membrane transporter/Ion channel, Neuroscience
Bioactivity
Ardeemin ((-) -Ardeemin) binds to P-glycoprotein, inhibiting the efflux of anticancer drugs from cells. In breast cancer xenograft models, Ardeemin can reverse the multidrug resistance phenotype of tumor cells and enhance their sensitivity to anticancer drugs.
Smiles
[C@@](C=C)(C)(C)[C@]12[C@](N3[C@@](C1)(C=4N([C@H](C)C3=O)C(=O)C=5C(N4)=CC=CC5)[H])(NC=6C2=CC=CC6)[H]
Molecular Formula
C26H26N4O2
Molecular Weight
426.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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