(±) -Aiphanol

(±) -Aiphanol, a newly identified stilbenolignan analog, demonstrates notable anti-inflammatory properties by inhibiting COX-1 and COX-2. It shows a robust inhibitory effect on COX-1 (IC 50 = 1.9 ?M) and a milder effect on COX-2 (IC 50 = 9.9 ?M) [1]. Additionally, (±) -Aiphanol effectively inhibits VEGFR2 with an IC 50 of 0.92 µM, blocking angiogenesis and inducing apoptosis through VEGFR2 and COX2 inhibition. It is also orally active [2].