RGMA Protein, Human, Recombinant (His & Avi)

Repulsive guidance molecule (RGM) is a glycosylphosphatidylinositol (GPI) -anchored glycoprotein that has diverse functions in the developing and pathological central nervous system (CNS) . The binding of RGM to its receptor neogenin regulates axon guidance, neuronal differentiation, and survival during the development of the CNS. RGMa induces T cell activation in experimental autoimmune encephalomyelitis (EAE), which is the animal model of multiple sclerosis (MS) . RGM is expressed in pathogenic Th17 cells and induces neurodegeneration by binding to neogenin.