Fsh receptor-binding inhibitor fragment (bi-10)

FSH receptor-binding inhibitor fragment (bi-10) is a potent FSH antagonist. FSH receptor-binding inhibitor fragment (bi-10) blocks the binding of FSH to FSHR, and alteres FSH action at the receptor level. FSH receptor-binding inhibitor fragment (bi-10) results in the suppression of ovulation and causes follicular atresia of mice. FSH receptor-binding inhibitor fragment (bi-10) has the potential for utilizing to restrain the carcinogenesis of ovarian cancer by down-regulating overexpression of FSHR and ERβ in the ovaries[1].

Product Specifications

CAS Number

[163973-98-6]

UNSPSC

12352209

Target

GnRH Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/fsh-receptor-binding-inhibitor-fragment-bi-10.html

Purity

99.19

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@H](O)[C@H](N)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N1[C@@H](CCC1)C(N[C@@H](CC(N)=O)C(NCC(N[C@@H](CCC(O)=O)C(NCC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C42H67N13O19

Molecular Weight

1058.06

References & Citations

[1]Gong Zhuandi, et al. FSH receptor binding inhibitor restrains follicular development and possibly attenuates carcinogenesis of ovarian cancer through down-regulating expression levels of FSHR and ERβ in normal ovarian tissues. Gene. 2018 Aug 20;668:174-181.