CYP3A4-IN-3
Product Specifications
UNSPSC Description
CYP3A4-IN-3 is a high-affinity specific inhibitor of cytochrome P450 3A4 (CYP3A4) with the IC50 value of 0.075 μM. CYP3A4-IN-3 is a ritonavir analogue, but with a simpler structure and twice the inhibitory effect of ritonavir. CYP3A4-IN-3 is used as an antiviral agent and immunosuppressant[1].
Target Antigen
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cyp3a4-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCC1=CN=CC=C1)[C@@H](CC2=CC=CC=C2)SC[C@@H](NC(OC(C)(C)C)=O)CC3=CC=CC4=C3C=CC=C4
Molecular Weight
569.76
References & Citations
[1]Eric R Samuels, et al. An increase in side-group hydrophobicity largely improves the potency of ritonavir-like inhibitors of CYP3A4. Bioorg Med Chem. 2020 Mar 15;28(6):115349. doi: 10.1016/j.bmc.2020.115349. Epub 2020 Jan 31.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-150581/CYP3A4-IN-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-150581/
Clinical Information
No Development Reported
CAS Number
2562384-19-2
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