AO-176
Product Specifications
CAS Number
2691109-74-5
Target
Others
Related Pathways
Others
Bioactivity
AO-176 is a humanized anti-CD47 IgG2 monoclonal antibody. It induces tumor phagocytosis by blocking the interaction between CD47 and SIRPα. AO-176 preferentially binds to tumor cells over normal cells and directly kills tumor cells through a cell-autonomous mechanism, rather than via antibody-dependent cellular cytotoxicity (ADCC) . In tumor xenograft models, AO-176 demonstrates dose-dependent antitumor activity. This compound is applicable in cancer research, such as studies involving lymphoma.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LV786470 1.0 µg DNA
ST7-OT4 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)
Sign In for Pricing
View Details 
GTR15186358 1 Vial
Lentiviral mouse Aldh16a1 shRNA (UAS) - Lentiviral mouse Aldh16a1 shRNA (UAS, GFP) plasmid
Sign In for Pricing
View Details