HEI3090
Product Specifications
CAS Number
2377167-56-9
Target
Interleukin, P2X Receptor, IFNAR
Related Pathways
Immunology/Inflammation, Neuroscience, Membrane transporter/Ion channel
Bioactivity
HEI3090 is an activator of the P2X7R receptor. This compound enhances the production of IL-18 by stimulating dendritic cells that express P2X7R, which in turn promotes the production of IFN-γ by natural killer cells and CD4T cells within tumors, triggering a sustained anti-tumor response. Additionally, HEI3090 can be used to improve the efficacy of αPD-1 therapy in non-small cell lung cancer (NSCLC) .
Smiles
C(NC=1C=CC(Cl)=NC1)(=O)N2[C@H](C(NCC3=C(Cl)C=C(Cl)C=C3)=O)CCC2=O
Molecular Formula
C18H15Cl3N4O3
Molecular Weight
441.7
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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