YGT-31
Product Specifications
CAS Number
2835447-74-8
Bioactivity
YGT-31 is a PPARγ modulator with an IC50 of 1.72 μM and a Ki of 0.62 μM. It diminishes blood glucose levels and enhances insulin sensitivity in a type 2 diabetes model in db/db mice by inhibiting CDK5-mediated phosphorylation of PPARγ-Ser273. Additionally, YGT-31 exhibits anti-steatotic effects in a mouse model of non-alcoholic fatty liver disease (NAFLD) .
Smiles
O=C1C=C(OC=2C=C(OCC(=O)NCC3=CC=C(C=C3)C(F)(F)F)C=C(O)C12)C=4C=CC=CC4
Molecular Formula
C25H18F3NO5
Molecular Weight
469.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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