HPO-DAEE
Product Specifications
CAS Number
1895934-61-8
Target
ROS|||Reactive Oxygen Species|||HDAC
Related Pathways
DNA Damage/DNA Repair|||Metabolism|||Immunology/Inflammation|||Chromatin/Epigenetic|||NF-?B
Bioactivity
HPO-DAEE (4-Hydroperoxy-2-decenoic acid ethyl ester) performs multiple roles in cellular processes, primarily enhancing nuclear accumulation of Nrf2 and activating the antioxidant response element (ARE) . It upregulates antioxidant genes such as HO-1 through Nrf2-ARE signaling and initiates the generation of reactive oxygen species. Additionally, HPO-DAEE inhibits histone deacetylase, promoting the expression of extracellular superoxide dismutase via histone acetylation. It offers protection against 6-hydroxydopamine-induced cell death by activating the Nrf2-ARE and eIF2?-ATF4 pathways [1].
Smiles
C(C=CC(OCC)=O)(CCCCCC)OO
Molecular Formula
C12H22O4
Molecular Weight
230.3
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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