EGFR-IN-97
Product Specifications
CAS Number
3020681-05-1
Target
EGFR, Apoptosis
Related Pathways
Apoptosis, JAK/STAT signaling, Tyrosine Kinase/Adaptors, Angiogenesis
Bioactivity
EGFR-IN-97 (compound 6q), an EGFR inhibitor, demonstrates effectiveness in inhibiting Ba/F3-EGFR L858R/T790M/C797S and Ba/F3-EGFR Del19/T790M/C797S cells, exhibiting IC 50 values of 0.42 μM and 0.41 μM, respectively. Additionally, at a concentration of 0.8 μM, EGFR-IN-97 is capable of inducing apoptosis in NCI-H1975-EGFR L858R/T790M/C797S cells [1].
Smiles
[C@@H](C(NC1=CC=C(NC2=NC(N)=NC=C2)C=C1)=O)(N3CC=4C(C3=O)=CC=C(C4)C5=CC=C(C=C5)N6CCN(C)CC6)C7=CC=CC=C7
Molecular Formula
C37H36N8O2
Molecular Weight
624.73
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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