TM5441 sodium

TM5441, an orally bioavailable plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 values ranging from 13.9 to 51.1 ?M, effectively induces intrinsic apoptosis across multiple human cancer cell lines. Additionally, it mitigates N?-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence [1] [2].