LL-K9-3
Product Specifications
CAS Number
2809353-52-2
Target
Others|||c-Myc|||Apoptosis|||PROTACs|||CDK
Related Pathways
Others|||PROTAC|||Apoptosis|||Cell Cycle/Checkpoint
Bioactivity
LL-K9-3, a selective hydrophobic tagging technology (HyT) -based degrader, specifically targets the CDK9-cyclin T1 complex, displaying DC50 values of 589 nM for cyclin T1 and 662 nM for CDK9. This compound consists of the CDK9 inhibitor, SNS 032, linked to a hydrophobic tag via a glycol linker. Notably, LL-K9-3 does not affect the degradation of other CDKs (CDK1, 2, 4, 5, 6, and 7) . Tested in 22RV1 cells, it effectively reduces androgen receptor (AR) and cMyc expression by inducing the selective and synchronous degradation of CDK9 and cyclin T1.
Smiles
O=S(CCNC(CO[C@H]1[C@@H](CC[C@H](C1)C)C(C)C)=O)(N2CCC(CC2)C(NC3=NC=C(SCC4=NC=C(C(C)(C)C)O4)S3)=O)=O
Molecular Formula
C31H49N5O6S3
Molecular Weight
683.94
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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