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P-gp/BCRP-IN-2

Product Specifications

Target

P-gp, BCRP, Others

Related Pathways

Neuroscience, Membrane transporter/Ion channel, Others

Bioactivity

P-gp/BCRP-IN-2 (compound 15), an oxadiazole derivative, functions as a dual inhibitor targeting both the ABC transporter P-glycoprotein (IC50: 1.6 nM) and BCRP (IC50: 600 nM) . Additionally, it bolsters the anti-proliferative impact of Doxorubicin in the drug-resistant HT29/DX and MDCK-MDR1 human adenocarcinoma colon cancer cell lines [1].

Molecular Formula

C32H35N3O6

Molecular Weight

557.64

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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