NSC194598
Product Specifications
CAS Number
5358-76-9
Target
C-RET, Others
Related Pathways
Tyrosine Kinase/Adaptors, Apoptosis, Others
Bioactivity
NSC194598, a p53 DNA-binding inhibitor, demonstrates an in vitro IC50 of 180 nM and an in vivo range of 2-40 μM. It disrupts the transcriptional activation of the mutated RET gene in human medullary thyroid carcinoma TT cells and is utilized in research investigating acute toxicity in normal tissues due to radiation and chemotherapy [1] [2].
Smiles
O=N=1C(=NC2=CC=CC=3C=4C=CC=CC4C1C23)CN5CCCCC5
Molecular Formula
C20H19N3O
Molecular Weight
317.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
bs-13248R-PE-Cy7 100 µL
G protein alpha 16 Polyclonal Antibody, PE-Cy7 Conjugated
Sign In for Pricing
View Details 
orb2915720-01 20 µg
Recombinant Pseudomonas stutzeri Cobalamin biosynthesis protein CobD (cobD)
Sign In for Pricing
View Details orb2915720-02 100 µg
Recombinant Pseudomonas stutzeri Cobalamin biosynthesis protein CobD (cobD)
Sign In for Pricing
View Details 
150717 100 µg
SLC9A3R2 (Na (+) /H (+) Exchange Regulatory Cofactor NHE-RF2, NHERF-2, NHE3 Kinase A Regulatory Protein E3KARP, SRY-interacting Protein 1, SIP-1, Sodium-hydrogen Exchanger Regulatory Factor 2, Solute Carrier Family 9 Isoform A3 Regulatory Factor 2, Tyrosine Kinase Activator Protein 1, TKA-1, NHERF2, MGC104639) discontinued
Sign In for Pricing
View Details 240482-01 250 mg
Na-Boc-Nw, Nw'-bis-Z-L-arginine N-hydroxysuccinimide ester
Sign In for Pricing
View Details