GSK3735967
Product Specifications
CAS Number
2170136-86-2
Target
Others|||DNA Methyltransferase
Related Pathways
Others|||Chromatin/Epigenetic
Bioactivity
GSK3735967 is a selective, reversible, non-nucleoside inhibitor targeting DNMT1, demonstrating an IC50 value of 40 nM. It features a planar dicyanopyridine core designed to specifically interact with DNMT1-bound hemimethylated CpG dinucleotides. Additionally, GSK3735967 possesses three binding sites, with one uniquely capable of binding to histone H4K20me3 [1] [2].
Smiles
C(#N)C1=C(N=C(SCC2=CC=C(CNC(CN)=O)C=C2)C(C#N)=C1CC)N3CCN(C)CCC3
Molecular Formula
C25H31N7OS
Molecular Weight
477.62
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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