GSK761
Product Specifications
Target
Others, Epigenetic Reader Domain
Related Pathways
Others, Chromatin/Epigenetic
Bioactivity
GSK761, a selective inhibitor of speckled 140 kDa (SP140), exhibits an IC50 value of 77.79 nM. It impedes the differentiation of monocytes into inflammatory macrophages and attenuates lipopolysaccharide (LPS) -induced inflammatory activation. Furthermore, GSK761 promotes the generation of CD206+ regulatory macrophages through the inhibition of SP140.
Smiles
CC(C)(C)OCCC1=CC(=CC=C1)NC(=O)C2=CC=C(C=C2)C3=NC4=C(N3C)C=CC(=C4)C(=O)NC5=CC=CC(=C5)CCOC(C)(C)C
Molecular Formula
C40H46N4O4
Molecular Weight
646.82
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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