YLT-11
Product Specifications
Target
Apoptosis|||PLK|||Others
Related Pathways
Apoptosis|||Others|||Cell Cycle/Checkpoint
Bioactivity
YLT-11 is a potent, selective, and orally active inhibitor of polo-like kinase 4 (PLK4), with dissociation constant (Kd) values of >10000 nM for PLK1, 653 nM for PLK2, >10000 nM for PLK3, and 5.2 nM for PLK4. It demonstrates antiproliferative effects, induces apoptosis, and causes cell cycle arrest at the G2/M phase, highlighting its anticancer activity.
Smiles
CC(=O)NC1=NC=CC(=N1)C2=CC3=C(C=C2)C(=NN3)/C=C/C4=CC=C(C=C4)CN(C)C
Molecular Formula
C24H24N6O
Molecular Weight
412.49
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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