OTS193320
Product Specifications
CAS Number
2093401-33-1
Target
Apoptosis|||Histone Methyltransferase|||Others
Related Pathways
Chromatin/Epigenetic|||Others|||Apoptosis
Bioactivity
OTS193320, an imidazopyridine compound, acts as an inhibitor of SUV39H2 methyltransferase activity. It effectively reduces global histone H3 lysine 9 tri-methylation levels in breast cancer cells, promoting apoptotic cell death. When combined with Doxorubicin (DOX), OTS193320 enhances the reduction of ?-H2AX levels and decreases cancer cell viability more significantly than when either agent is used alone.
Smiles
O(C)C1=C(C2=CN3C(=N2)C=C(N[C@@H]4CC[C@H](NCC5=CC=C(N(=O)=O)C=C5)CC4)C=C3)C=C(Cl)C(OC)=C1
Molecular Formula
C28H30ClN5O4
Molecular Weight
536.02
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/62151386455867516/T73225
Available Sizes
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