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(+) -Norfenfluramine

Product Specifications

CAS Number

19036-73-8

Target

5-HT Receptor

Related Pathways

Neuroscience, GPCR/G Protein

Bioactivity

(+) -Norfenfluramine, the principal hepatic metabolite of (+) -fenfluramine, acts as a selective agonist for the 5-HT2B receptor, exhibiting a potent K i of 11.2 nM. It significantly promotes the hydrolysis of inositol phosphates and heightens intracellular Ca2+ levels. This compound is valuable in the study of primary pulmonary hypertension and valvular heart disease.

Smiles

C[C@H](N)Cc1cccc(c1)C(F)(F)F

Molecular Formula

C10H12F3N

Molecular Weight

203.2

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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