Lambda Light Chain Antibody Cocktail
This antibody cocktail is specific to lambda light chain of immunoglobulin and shows no cross-reaction with kappa light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. In general, the ratio of Kappa to Lambda is 3:1. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Lambda light chain antibody is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 0.5-1ug/10^6 cells, Immunofluorescence: 0.5-1 µg/mL, Western blot: 0.5-1 µg/mL
Host
Mouse
Reactivity
Human
Immunogen
Purified human Ig (LcN-2 and ICO-106) was used as the immunogen for this Lambda Light Chain antibody cocktail.
Clonality
Monoclonal
Isotype
IgG2a κ,IgG1 κ
Clone
LcN-2 + ICO-106
Applications
FACS, IF, WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1X PBS, pH 7.4
Reconstitution
Store the Lambda Light Chain antibody cocktail at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Lambda Light Chain antibody cocktail is available for research use only.
Storage Conditions
Store the Lambda Light Chain antibody cocktail at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cell surface, cytoplasmic and secreted
Image Legend
IHC testing of human tonsil stained with Lambda Light Chain antibody cocktail (LcN-2 + ICO-106) .
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