APcK110
Product Specifications
CAS Number
1001083-74-4
Target
Others|||c-Kit
Related Pathways
Tyrosine Kinase/Adaptors|||Others
Bioactivity
APcK110 is a novel Kit inhibitor . APcK110 inhibits proliferation of the mastocytosis cell line HMC1.2 and the SCF-responsive cell line OCI/AML3 in a dose-dependent manner . APcK110 is a more potent inhibitor of OCI/AML3 proliferation than the clinically used Kit inhibitors imatinib and dasatinib and at least as potent as cytarabine. APcK110 inhibits the phosphorylation of Kit, Stat3, Stat5, and Akt in a dose-dependent fashion, showing activity of APcK110 on Kit and its downstream signaling pathways . APcK110 may have potent application in AML.
Smiles
FC1=CC=C(C=2C=3C(=NC(=CC3)C4=CC(OC)=CC(OC)=C4)NN2)C=C1
Molecular Formula
C20H16FN3O2
Molecular Weight
349.36
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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