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AZ1495

AZ1495 is a potent and orally bioavailable small molecule inhibitor of IRAK4 (IC50=5 nM) and IRAK1 (IC50=23 nM) . It demonstrates research utility in models of diffuse large B-cell lymphoma, particularly for investigating oncogenic signaling driven by the MYD88L265P mutation in both cellular and in vivo studies.

Product Specifications

CAS Number

2196204-23-4

Product Name Alternative

Cancer, AZ1495, AZ-1495, AZ 1495, CLK4, CLK2, CLK1, diffuse large B-cell lymphoma (DLBCL), Inhibitor, haspin, Haspin Kinase, HaspinKinase, inhibit, IRAK4, IRAK, IRAK-1, IRAK1, IL-1R associated kinase, interleukin-1 receptor associated kinase 1 (IRAK1), interleukin-1 receptor associated kinase 4 (IRAK4), Interleukin-1 receptor associated kinase, weak base

Field of Research

Cell Biology, Immunology & Inflammation, Signal Transduction

Purity

98.36% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.59 mM) ; DMSO:10 mg/mL (25.94 mM)

Smiles

C1CC (CCO1) c1c[nH]c2ncnc (N[C@H]3CC[C@@H] (CC3) N3CCOCC3) c12

Molecular Formula

C21H31N5O2

Molecular Weight

385.5

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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