GNE-900

Product Specifications

CAS Number

1200126-26-6

Target

Apoptosis|||Chk

Related Pathways

Cell Cycle/Checkpoint|||Apoptosis

Purity

0.992

Bioactivity

GNE-900 is an ATP-competitive ChK1 inhibitor with selective and oral activity.GNE-900 inhibits ChKl and ChK2 with IC50 values of 0.0011 and 1.5 µM, respectively.GNE-900 enhances DNA damage and induces apoptosis. GNE-900 has antitumor activity.

Smiles

C(#N)C=1C=C2C=3C(NC2=CN1)=NC=C(C3)C4=CC=C(CN5CCCCC5)C=C4

Molecular Formula

C23H21N5

Molecular Weight

367.45

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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