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BE-16627B

Product Specifications

CAS Number

137530-61-1

Target

Others

Related Pathways

Others

Bioactivity

BE-16627B is a novel metalloproteinase (MP) inhibitor isolated from Streptomyces sp. BE16627B selectively inhibited MPs such as human stromelysin and 92 kD gelatinase. After the cells were cultured with BE16627B for 5 days, BE16627B inhibited MP activity in the primary culture supernatants from synovial cells in a dose-dependent fashion without showing apparent cytotoxicity or affecting the production and secretion of MPs. Its IC50 for active collagenolysis before activation by trypsin was 25 microM.

Smiles

C(C(N[C@H](C(N[C@@H]([C@@H](C)C)C(O)=O)=O)CO)=O)(CC(NO)=O)CC(C)C

Molecular Formula

C16H29N3O7

Molecular Weight

375.42

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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