What is the catalog number for Recombinant human Podocalyxin protein?

The catalog number for Recombinant human Podocalyxin protein is ATGP4090-050.

What sizes are available for Recombinant human Podocalyxin protein?

Recombinant human Podocalyxin protein is available in the following size(s): 50 µg.

Is Recombinant human Podocalyxin protein in stock?

Recombinant human Podocalyxin protein is currently made to order / not held in immediate stock. Contact us for lead time.

Recombinant human Podocalyxin protein

Podocalyxin, also known as PODXL, is a member of the CD34 sialomucin protein family. It is present in glomerular podocytes, endothelial cells, glandular cells in fallopian tube, uterus. A soluble form of Podocalyxin can be released into the urine of women with pre-eclampsia. It has been shown to interact with Sodium-hydrogen exchange regulatory cofactor 2. And Its interactions with L-Selectin and E-Selectin mediate the tethering of lymphocytes and metastatic tumor cells to the vascular endothelium. It is upregulated in a number of cancers and is frequently associated with poor prognosis. Based on patient survival data, high level of PODXL transcripts in tumor cells is associated with poor prognosis in renal cancer. Recombinant human Podocalyxin, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

PODXL, Podocalyxin, Podocalyxin isoform 2, GCTM, GCTM-2 antigen, Gp200, Podocalyxin-like protein 1, PCLP, PCLP1, PCLP-1, PCpodocalyxin, podocalyxin-like, PDX, gp135, PC, PODXL1

Expression System

HEK293

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

43.1kDa (416aa)

Additionnal Information

ATGP4090-10 µg, ATGP4090-20 µg, ATGP4090-50 µg, ATGP4090-100 µg, ATGP4090-250 µg, ATGP4090-500 µg, ATGP4090-1 mg, ATGP4090-10, ATGP4090-20, ATGP4090-50, ATGP4090-100, ATGP4090-250, ATGP4090-500, ATGP4090-1

References & Citations

Nielsen, J.S. and K.M. McNagny (2009) J. Am. Soc. Nephrol. 20:1669-1676.; ; Nielsen JS, McNagny KM (2008) . Journal of Cell Science. 121: 3683–3692.; ; Takeda T, et al. (2001) . The Journal of Clinical Investigation. 108: 289–301.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol.

Scientific Category

Signal Transduction, Cytoskeleton

NCBI Accession Number

NP_005388.2

Uniprot Accession Number

O00592

Species

Human

N Terminal Sequence

Asp

AA Sequence

SPSPSPS PSQNATQTTT DSSNKTAPTP ASSVTIMATD TAQQSTVPTS KANEILASVK ATTLGVSSDS PGTTTLAQQV SGPVNTTVAR GGGSGNPTTT IESPKSTKSA DTTTVATSTA TAKPNTTSSQ NGAEDTTNSG GKSSHSVTTD LTSTKAEHLT TPHPTSPLSP RQPTSTHPVA TPTSSGHDHL MKISSSSSTV AIPGYTFTSP GMTTTLPSSV ISQRTQQTSS QMPASSTAPS SQETVQPTSP ATALRTPTLP ETMSSSPTAA STTHRYPKTP SPTVAHESNW AKCEDLETQT QSEKQLVLNL TGNTLCAGGA SDEKLISLIC RAVKATFNPA QDKCGIRLAS VPGSQTVVVK EITIHTKLPA KDVYERLKDK WDELKEAGVS DMKLGDQGPP EEAEDRFSMP