KR-67607
Product Specifications
CAS Number
1401564-00-8
Target
Others
Related Pathways
Others
Bioactivity
KR-67607, also known as NTX-101 is novel selective 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitor. KR-67607 decreased 4-hydroxynonenal expression and increased antioxidant and mucus secretion in BAC-treated rat eyes. KR-67607 showed its protective effects against ischemia-reperfusion-induced eye injury. KR-67607 effectively reduced cortisol levels in mouse eyes and maintained the trabecular meshwork (TM) structure in the presence of transient ischemic stress. Furthermore, KR-67607 reversed the elevation of intra-ocular pressure (IOP), suggesting that the TM structure maintained by KR-67607 prevented the excessive rise in IOP that exacerbates glaucoma.
Smiles
C(N)(=O)C12C[C@@]3([C@@H](NC(CN4S(=O)(=O)N(CC(C)C4)C5=C(Cl)C=C(C(F)(F)F)C=C5Cl)=O)[C@](C1)(CC(C2)C3)[H])[H]
Molecular Formula
C24H29Cl2F3N4O4S
Molecular Weight
597.48
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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