Zopolrestat

Zopolrestat is a potent inhibitor of aldose reductase (IC50 = 3.1 nM) . (In Vitro) :Zopolrestat is a potent inhibitor of the enzymatic reduction of glyceraldehyde and glucose. (In Vivo) :After the administration of Zopolrestat (2.5 mg/kg-50 mg/kg; p.o), the ED50s in reversing already elevated sorbitol accumulation in rat sciatic nerve, retina, and lens in a chronic test were 1.9, 17.6, and 18.4 mg/kg, respectively.