Piragliatin
Product Specifications
CAS Number
625114-41-2
Target
Others, Glucokinase
Related Pathways
Others, Metabolism
Bioactivity
Piragliatin, also known as RO4389620, is a glucokinase activator. Piragliatin greatly enhances glucose-induced pancreatic islet respiration and insulin release. Piragliatin lowers plasma glucose both in the postabsorptive state and after a glucose challenge in patients with type 2 diabetes mellitus. Piragliatin has an acute glucose-lowering action in patients with mild type 2 diabetes, mainly mediated through a generalized enhancement of β-cell function and through fasting restricted changes in glucose turnover.
Smiles
[C@H](C[C@H]1CCC(=O)C1)(C(NC=2C=NC=CN2)=O)C3=CC(Cl)=C(S(C)(=O)=O)C=C3
Molecular Formula
C19H20ClN3O4S
Molecular Weight
421.9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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