Orphenadrine
Product Specifications
CAS Number
83-98-7
Target
IGluR, Cholinesterase (ChE), Cytochromes P450, NMDAR, Sodium Channel, AChR
Related Pathways
Membrane transporter/Ion channel, Neuroscience, Metabolism
Purity
0.9938
Bioactivity
Orphenadrine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist that inhibits clonal HERG channels in a concentration-dependent manner, producing an IC of 0.85 μM in HEK cells.Orphenadrine is an antagonist of central and peripheral muscarinic receptors. Attenuation is blocked by mutations in pore residues Y652 or F656. Orphenadrine has antispasmodic, analgesic, and anticholinergic activity and protects against glutamatergic neurotoxicity in vitro and in vivo.Orphenadrine has inhibitory effects on sodium channels and can be used in the treatment of Parkinson's disease.
Smiles
C(OCCN(C)C)(C1=C(C)C=CC=C1)C2=CC=CC=C2
Molecular Formula
C18H23NO
Molecular Weight
269.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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