Dilmapimod tosylate
Product Specifications
CAS Number
937169-00-1
Target
Autophagy, p38 MAPK, Others
Related Pathways
Others, Autophagy, MAPK
Bioactivity
Dilmapimod tosylate is a potent p38 mitogen-activated protein kinase (MAPK) inhibitor. It was investigated for its anti-inflammatory effect in non-head injury trauma patients at risk for developing acute respiratory distress syndrome. IL-1β was identified as a gene regulated by dilmapimod that could influence c-reactive protein levels. Dilmapimod had been in phase III clinical trials by GlaxoSmithKline for the treatment of rheumatoid arthritis, neuropathic pain, coronary artery disease (CAD) and chronic obstructive pulmonary disease (COPD) .
Smiles
Cc1ccc(cc1)S(O)(=O)=O.Cc1cc(F)ccc1-c1nc(NC(CO)CO)nc2n(-c3c(F)cccc3F)c(=O)ccc12
Molecular Formula
C30H27F3N4O6S
Molecular Weight
628.62
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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