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Adriforant

Product Specifications

CAS Number

943057-12-3

Target

Histamine Receptor

Related Pathways

Neuroscience|||Immunology/Inflammation|||GPCR/G Protein

Purity

0.9984

Bioactivity

Adriforant (PF-3893787, ZPL-3893797) is a competitive H4 (histamine receptor 4) antagonist that antagonizes histamine-induced phosphorylation of ERK, normalizes histamine-induced transcriptional changes in mast cells and reduces histamine-dependent Ca2+ fluxes in neurons, which alleviates itching and skin inflammation in mice

Smiles

N(C)[C@H]1CN(CC1)C=2C=C(NCC3CC3)N=C(N)N2

Molecular Formula

C13H22N6

Molecular Weight

262.35

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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