What is the catalog number for Hedgehog IN-11?

The catalog number for Hedgehog IN-11 is T212033.

What sizes are available for Hedgehog IN-11?

Hedgehog IN-11 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does Hedgehog IN-11 come in?

Hedgehog IN-11 is available in 2 different pack sizes.

Is Hedgehog IN-11 in stock?

Hedgehog IN-11 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Hedgehog IN-11?

Hedgehog IN-11 is manufactured by Molfinity.

What is the estimated delivery time for Hedgehog IN-11?

Estimated delivery time for Hedgehog IN-11 is approximately 10 business day(s), depending on your location.

Hedgehog IN-11

Product Specifications

Target

Hedgehog/Smoothened, DNA Methyltransferase, Apoptosis

Related Pathways

GPCR/G Protein, Stem Cells, Apoptosis, Chromatin/Epigenetic

Bioactivity

HedgehogIN-11 is an orally active Hedgehog inhibitor. It reduces resistance to Temozolomide (TMZ) by downregulating O6-methylguanine-deoxyribonucleotides methyltransferase (MGMT) expression through the Hedgehog pathway. HedgehogIN-11 significantly inhibits the migration and invasion of TMZ-resistant glioblastoma cells and induces apoptosis. Computational modeling predicts good blood-brain barrier penetration for HedgehogIN-11. This compound is applicable for glioblastoma (GBM) research.