Anti-MARCKS (Phospho-Ser162)
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008]
Product Specifications
Reactivity
Human,Mouse,Rat
Immunogen
The antibody was produced against synthesized phosphopeptide derived from human MARCKS around the phosphorylation site of serine 162 (K-K-SP-F-K).
Clonality
Polyclonal
Type
Antibodies-Polyclonal
Applications
ICC/IF
Concentration
100ug/100ul
Purity
Affinity purified
Buffer
Rabbit IgG in phosphate buffered saline (without Mg<sup>2</sup>+ and Ca<sup>2</sup>+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Shipping Conditions
Ice Pack
Storage Conditions
Fragment
IgG
Specificity
MARCKS (Phospho-Ser162) Antibody detects endogenous levels of MARCKS only when phosphorylated at serine 162.
Applications Notes
IF:1:100~1:200
CAS Number
9007-83-4
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