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MET Transcription-IN-1

Product Specifications

CAS Number

3082125-66-1

Target

Apoptosis, c-Met/HGFR

Related Pathways

Tyrosine Kinase/Adaptors, Apoptosis

Bioactivity

MET Transcription-IN-1 (Compound C3) is an orally active inhibitor of MET transcription that efficiently binds to and stabilizes the G-quadruplex in the MET promoter region, thereby inhibiting c-Met expression. It can overcome resistance caused by specific c-Met mutations and effectively inhibits tumor cell proliferation, migration, and invasion, inducing cell cycle arrest and apoptosis. This compound exhibits antitumor activity and is applicable in the study of tumors such as non-small cell lung cancer.

Smiles

N1=CC=CC=2C1=C3N=CC=CC3=C4NC(=NC24)C=5OC(=CC5)C=6C=CC=C(OC)C6

Molecular Formula

C24H16N4O2

Molecular Weight

392.41

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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