OXPHOS-IN-2
Product Specifications
Target
AMPK|||Apoptosis|||OXPHOS|||Mitochondrial Metabolism|||Nrf2|||ROS
Related Pathways
Immunology/Inflammation|||Metabolism|||Apoptosis|||PI3K/Akt/mTOR signaling|||Chromatin/Epigenetic
Bioactivity
OXPHOS-IN-2 is an orally active inhibitor of OXPHOS, demonstrating potent inhibitory effects in PC9 cells (IC50= 12.3 nM) and Bxpc-3 cells (IC50= 250 nM in glucose medium, IC50= 17.5 nM in galactose medium) . It modulates the NADH/NAD+ ratio and decreases ATP levels. OXPHOS-IN-2 induces apoptosis in tumor cells by activating reactive oxygen species (ROS) and downregulating Nrf2 levels. This compound is applicable for research in cancers such as non-small cell lung cancer and pancreatic cancer.
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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