Z1609609733
Product Specifications
CAS Number
2375374-15-3
Target
Dehydrogenase
Related Pathways
Metabolism
Bioactivity
Z1609609733 (Compound 18) is a non-covalent inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH) with an IC50 of 1.46 μM. It effectively suppresses serine synthesis, interferes with cancer metabolism, and completely halts cell proliferation.
Smiles
O=C(OC(OC(=O)C(C=1C=NC=CC1)C2=CC=C(C=C2)C3(NC(=O)C4=CC=5C(Cl)=C(Cl)C=CC5N4C)COC3)C)C
Molecular Formula
C30H27Cl2N3O6
Molecular Weight
596.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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