What is the catalog number for SPA-10091-HCl?

The catalog number for SPA-10091-HCl is T207790.

What sizes are available for SPA-10091-HCl?

SPA-10091-HCl is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does SPA-10091-HCl come in?

SPA-10091-HCl is available in 2 different pack sizes.

Is SPA-10091-HCl in stock?

SPA-10091-HCl is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures SPA-10091-HCl?

SPA-10091-HCl is manufactured by Molfinity.

What is the estimated delivery time for SPA-10091-HCl?

Estimated delivery time for SPA-10091-HCl is approximately 10 business day(s), depending on your location.

SPA-10091-HCl

Product Specifications

Target

Others

Related Pathways

Others

Bioactivity

SPA-10091-HCl is a DOT1L degrader that selectively degrades the DOT1L protein via the nuclear ubiquitin-proteasome pathway, thereby inhibiting H3K79 methylation in CRPC cells. It also inhibits DOT1L enzymatic activity (IC50 = 0.87 μM), induces apoptosis, and significantly suppresses tumor growth in vivo.