P53 Stabilizer 2
Product Specifications
CAS Number
2531685-87-5
Target
MDM-2/p53|||Apoptosis|||Chk
Related Pathways
Cell Cycle/Checkpoint|||Apoptosis
Bioactivity
P53 Stabilizer 2 (Compound 17a16) is a p53 stabilizing agent. It can induce S-phase arrest and apoptosis in both p53-functional and p53-deficient cancer cells. Additionally, p53 Stabilizer 2 triggers mitochondrial stress and activates two immune checkpoint pathways: NA-PKcs dependent p53 stabilization and the ATR-Chk1 axis activation. It also inhibits tumor growth in p53-deficient xenograft models.
Smiles
O(C)C=1C=2[C@@](N(C)CCC2C(C[Se]C3CCCCCC3)=C4C1OCO4)([C@@]5(C=6C(C(=O)O5)=C(OC)C(OC)=CC6)[H])[H]
Molecular Formula
C30H37NO7Se
Molecular Weight
602.58
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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