(S, R, S) -AHPC-Boc derivative 1
Product Specifications
CAS Number
2086298-33-9
Target
MALT
Related Pathways
Immunology/Inflammation
Bioactivity
(S, R, S) -AHPC-Boc derivative 1 (Compound 80-9; VH032-Boc derivative 1) is a selective proteasomal degrader targeting MALT1, which recruits the E3 ubiquitin ligase CRBN to form a ternary complex with MALT1. This interaction leads to the ubiquitination and subsequent proteasomal degradation of MALT1. By disrupting the CBM complex, (S, R, S) -AHPC-Boc derivative 1 inhibits the NF-κB signaling pathway and shows potential in inducing apoptosis in ABC-DLBCL cells. It holds promise for research into MALT1-dependent cancers, such as diffuse large B-cell lymphoma (DLBCL) .
Smiles
C([C@@H](NC(OC(C)(C)C)=O)C(C)(C)C)(=O)N1[C@H](C(N[C@@H](CO)C2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1
Molecular Formula
C28H40N4O6S
Molecular Weight
560.705
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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