E0924G
Product Specifications
CAS Number
2909474-29-7
Target
PPAR
Related Pathways
DNA Damage/DNA Repair, Metabolism
Bioactivity
E0924G is an orally active PPARδ agonist with an EC50 of 2.82 μM. It enhances the upregulation of osteoprotegerin (OPG) expression, with an EC50 of 0.29 μM. E0924G reduces RANKL-induced osteoclast differentiation and inhibits F-actin ring formation in RAW264.7 macrophages. Additionally, E0924G modulates bone density and bone loss in models of ovariectomy (OVX) and age-related osteoporosis.
Smiles
O=C(NC1=NC=CC(OC)=C1)C=2OC(=CC2)C
Molecular Formula
C12H12N2O3
Molecular Weight
232.24
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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