DHICA
Product Specifications
CAS Number
4790-08-3
Target
Endogenous Metabolite, DUB, Arrestin, GPCR, PARP
Related Pathways
Chromatin/Epigenetic, Cell Cycle/Checkpoint, Endocrinology/Hormones, DNA Damage/DNA Repair, GPCR/G Protein, Metabolism, Ubiquitination
Bioactivity
DHICA (5,6-Dihydroxyindole-2-carboxylic acid) is an intermediate in melanin synthesis and a component of eumelanin, as well as acting as a moderate potency agonist of GPR35. In the U2OS cell line, DHICA demonstrates the ability to induce β-arrestin translocation signaling with an EC50 value of 23.2 μM. Additionally, it plays a significant role in promoting and protecting against DNA damage.
Smiles
O=C(O)C1=CC=2C=C(O)C(O)=CC2N1
Molecular Formula
C9H7NO4
Molecular Weight
193.16
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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