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AZ 14145845

Product Specifications

CAS Number

2830555-70-7

Bioactivity

AZ 14145845, a potent and highly selective dual Mer/Axl kinase inhibitor (pIC50 = 7 nM and 7.8 nM in pAxl and pMer, respectively), demonstrates significant efficacy in reducing tumor growth in a dose-dependent manner within the Mer and Axl kinase Ba/F3 tumor xenograft model in vivo. When combined with anti-PD1 antibodies and ionizing radiation, this compound enhances survival rates in mice bearing MC38-derived tumors. Additionally, AZ 14145845 is orally bioavailable.

Smiles

N=1N=C(OC1C=2N=CC(=CC2C)C=3C(=NN(C3C)C)C)N(C)CC=4C=CC5=NC=C(C=6C=CC(=CC6)CN(C)C)N5C4

Molecular Formula

C32H35N9O

Molecular Weight

561.68

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Product Datasheet

https://www.targetmol.com/attachment/DataSheet/264725054661591142/T201375

Available Sizes

Curated Selection

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