PT109
Product Specifications
CAS Number
2059104-90-2
Target
SGK, JNK, ROCK
Related Pathways
Cell Cycle/Checkpoint, Stem Cells, MAPK, Cytoskeletal Signaling, Metabolism
Bioactivity
PT109 is a multikinase inhibitor that targets JNK and other kinases, playing a crucial role in anti-inflammatory, antioxidative, neurogenic, and synaptogenic processes. Specifically, PT109 inhibits JNK isoforms with the following IC50 values: JNK1 at 0.143 μM, JNK2 at 0.831 μM, and JNK3 at 0.285 μM. It also inhibits SGK isoforms (SGK1: IC50=1.34 μM; SGK2: IC50=5.6 μM; SGK3: IC50=26.4 μM) and ROCK2 (IC50=34 μM) . Additionally, PT109 reprograms polymorphic glioblastoma multiforme (GBM) into oligodendroglia via the PTBP1/PKM1/2 pathway and alters the metabolic pattern of GBM to exhibit antiglioma activity.
Smiles
O=C(NC1CCC(NC2=CC=CC=3C=NC=CC32)CC1)CCCCC4SSCC4
Molecular Formula
C23H31N3OS2
Molecular Weight
429.64
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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