PYR-41
PYR-41 is a selective, cell-permeable inhibitor of ubiquitin-activating enzyme (E1), blocks loading of immobilized His6-tagged E1 with ubiquitin with IC50 of <10 uM; does not affect the transfer of ubiquitin to E2 from E1, directly inhibits E1, but not E2; in addition to blocking ubiquitylation, PYR-41 increases total sumoylation in cells, attenuates cytokine-mediated nuclear factor-kappaB activation and inhibits nonproteasomal (Lys-63) ubiquitylation of TRAF6, also prevents the downstream ubiquitylation and proteasomal degradation of IκBα; inhibits degradation of p53 and activates the p53 transcriptional activity, demonstrates anti-tumor activity in animal studies.
Product Specifications
CAS Number
418805-02-4
Product Name Alternative
PYR41 | PYR 41
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 46 mg/mL
Smiles
O=C (OCC) C1=CC=C (N2NC (/C (C2=O) =C/C3=CC=C ([N+] ([O-]) =O) O3) =O) C=C1
Molecular Formula
C17H13N3O7
Molecular Weight
371.3
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzoic acid, 4-[4-[ (5-nitro-2-furanyl) methylene]-3,5-dioxo-1-pyrazolidinyl]-, ethyl ester
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