PROTAC SMARCA2 degrader-14
Product Specifications
CAS Number
2568276-73-1
Target
PROTACs
Related Pathways
PROTAC
Bioactivity
SMARCA2 degrader-3 (compound I-323) is a PROTAC molecule designed to target and degrade the SMARCA2 protein. In A549 cells, it exhibits a degradation half-maximal concentration (DC50) of less than 100 nM and achieves a maximum degradation rate (Dmax%) greater than 90% after 24 hours of treatment.
Smiles
O=C1NC(=O)C(N2C(=O)C3=CC=C(C=C3C2=O)NC4CCC(N5CCC(N6N=CC(=C6)C=7C=C(N=NC7N)C=8C=CC=CC8O)CC5)CC4)CC1
Molecular Formula
C37H39N9O5
Molecular Weight
689.76
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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