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NCATS-SM4420

Product Specifications

CAS Number

1352286-61-3

Target

TSH Receptor

Related Pathways

GPCR/G Protein

Bioactivity

NCATS-SM4420 (Compound A35) is an orally effective ligand for the thyroid-stimulating hormone receptor (TSHR) that inhibits the proliferation of MDA-T32 and MDA-T85 cells both in vitro and in vivo, with IC50 values of 0.71 μM and 0.38 μM, respectively. Additionally, it suppresses the metastasis of MDA-T85F1 in mice. NCATS-SM4420 holds potential for research in the field of thyroid cancer.

Smiles

O=C(NC1=CC=C(OCC=2C=C(C=CC2OC)C3=NC=4C=CC=C(O)C4C(=O)N3CC=5C=CC=CC5)C=C1)C

Molecular Formula

C31H27N3O5

Molecular Weight

521.56

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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