NA-Ir

NA-Ir is a ferroptosis (Ferroptosis) inducer that targets mitochondrial DNA (mtDNA) and activates the cGAS-STING pathway to stimulate ferritin autophagy () . It also induces the production of reactive oxygen species (ROS) through photodynamic therapy (PDT), depletes glutathione (GSH), and downregulates glutathione peroxidase 4 (GPX4), thereby triggering lipid peroxidation and ferroptosis. NA-Ir exhibits enhanced anticancer activity under light exposure and selectively inhibits cancer cells with high H2S content.

F[P-](F)(F)(F)(F)F.[N-]=[N+]=NC1=CC=C2C(N(CCC(OCC3=CC(C4=CC(C)=CC=[N]4[Ir+3]567([C-]8=C(C9=[N]7C=CC=C9)C=CC=C8)[C-]%10=C(C%11=[N]6C=CC=C%11)C=CC=C%10)=[N]5C=C3)=O)C(C%12=CC=CC1=C%122)=O)=O