CycloScreen Cyclodextrins Kit

<strong>CycloScreen Cyclodextrins Kit</strong>_x000D_ <table width="492">_x000D_ <tbody>_x000D_ <tr>_x000D_ <td>Catalog number:</td>_x000D_ <td>K1010005</td>_x000D_ </tr>_x000D_ <tr>_x000D_ <td>Lot number:</td>_x000D_ <td>Batch Dependent</td>_x000D_ </tr>_x000D_ <tr>_x000D_ <td>Expiration date:</td>_x000D_ <td>Batch Dependent</td>_x000D_ </tr>_x000D_ <tr>_x000D_ <td>Package Content</td>_x000D_ <td>5 x 2 mL</td>_x000D_ </tr>_x000D_ <tr>_x000D_ <td>Content</td>_x000D_ <td>_x000D_ <ul>_x000D_ <li><span class="ILfuVd NA6bn"><span class="e24Kjd">α</span></span>-cyclodextrin (5%, 2 mL)</li>_x000D_ <li>(2-hydroxypropyl)-<span class="ILfuVd NA6bn"><span class="e24Kjd">α</span></span>-cyclodextrin (10%, 2 mL)</li>_x000D_ <li>methyl-<span class="ILfuVd"><span class="e24Kjd">β</span></span>-cyclodextrin (10%, 2 mL)</li>_x000D_ <li>(2-hydroxyprop yl)-<span class="ILfuVd"><span class="e24Kjd">β</span></span>-cyclodextrin (10%, 2 mL)</li>_x000D_ <li>(2-hydroxypropyl)-<span class="st">γ</span>-cyclodextrin (10%, 2 mL)</li>_x000D_ </ul>_x000D_ </td>_x000D_ </tr>_x000D_ <tr>_x000D_ <td>Supplied as:</td>_x000D_ <td>CycloScreen: Cyclodextrins Kit</td>_x000D_ </tr>_x000D_ <tr>_x000D_ <td>Keywords:</td>_x000D_ <td><span class="ILfuVd NA6bn"><span class="e24Kjd">α</span></span>-cyclodextrin, (2-hydroxypropyl)-<span class="ILfuVd NA6bn"><span class="e24Kjd">α</span></span>-cyclodextrin, methyl-<span class="ILfuVd"><span class="e24Kjd">β</span></span>-cyclodextrin, (2-hydroxypropyl)-<span class="ILfuVd"><span class="e24Kjd">β</span></span>-cyclodextrins, (2-hydroxypropyl)-<span class="st">γ</span>-cyclodextrins, cyclodextrin screening kit</td>_x000D_ </tr>_x000D_ <tr>_x000D_ <td>Storage:</td>_x000D_ <td>2-8°C (short term), -20°C (long term). Avoid repeated freeze-thaw.</td>_x000D_ </tr>_x000D_ </tbody>_x000D_ </table>_x000D_ &nbsp;_x000D_ _x000D_ <strong>Applications</strong>_x000D_ _x000D_ CycloScreen's cyclodextrins have been proven to be effective in several applications that include:_x000D_ <ul>_x000D_ <li>protein refolding and stabilization</li>_x000D_ <li>small chemicals and reagents stabilization</li>_x000D_ <li>quenching of certain detergents</li>_x000D_ <li>extension of reagent shelf-life</li>_x000D_ <li>specific binding of interfering substances</li>_x000D_ <li>transport of chemical compounds</li>_x000D_ </ul>_x000D_ With all three types of cyclodextrins included (<span class="ILfuVd NA6bn"><span class="e24Kjd">α</span></span>, <span class="ILfuVd"><span class="e24Kjd">β</span></span> and <span class="st">γ</span> as ranked by increasing molecular diameter), the kit offers the option to quickly screen for the most suitable cyclodextrin to a given application. Provided as highly concentrated solutions (5% and 10%), these cyclodextrins can be easily diluted to working concentrations. Working concentrations depend on the application, but typically range from 0.01% to 0.5%. Individual cyclodextrin solutions are available individually and in custom bulk amounts._x000D_ _x000D_ <strong>References</strong>_x000D_ <ul>_x000D_ <li style="list-style-type: none;">_x000D_ <ul>_x000D_ <li class="details">Cyclodext<a href="https://www.ncbi.nlm.nih.gov/pubmed/3542243">r</a>ins in drug carrier systems. Uekama K, Otagiri M. <span class="jrnl" title="Critical reviews in therapeutic drug carrier systems">Crit Rev Ther Drug Carrier Syst</span>. 1987;3(1):1-40.</li>_x000D_ <li class="details">Neutron diffraction of alpha, beta and gamma cyclodextrins: hydrogen bonding patterns. Hingerty B, Klar B, Hardgrove GL, Betzel C, Saenger W. <span class="jrnl" title="Journal of biomolecular structure &amp; dynamics">J Biomol Struct Dyn</span>. 1984 Aug;2(1):249-60.</li>_x000D_ <li>_x000D_ <p class="details">Inclusion compounds of cyclodextrins. Cramer F, Hettler H. <span class="jrnl" title="Die Naturwissenschaften">Naturwissenschaften</span>. 1967;54(24):625-32.</p>_x000D_ </li>_x000D_ <li>_x000D_ <p class="details">Analytical applications of enhanced drug luminescence. Baeyens WR, Ling BL. <span class="jrnl" title="Journal of pharmaceutical and biomedical analysis">J Pharm Biomed Anal</span>. 1989;7(12):1385-94.</p>_x000D_ </li>_x000D_ <li>Ma Z, Wang N, He H, Tang X. Pharmaceutical strategies of improving oral systemic bioavailability of curcumin for clinical application. <a href="https://pubmed.ncbi.nlm.nih.gov/31682912/"><span class="jrnl" title="Journal of controlled release : official journal of the Controlled Release Society">J Control Release</span></a>. 2019 Dec 28;316:359-380.</li>_x000D_ </ul>_x000D_ </li>_x000D_ </ul>