SYHA1815
Product Specifications
CAS Number
2760195-67-1
Target
C-RET|||VEGFR|||c-Myc
Related Pathways
Apoptosis|||Angiogenesis|||Tyrosine Kinase/Adaptors|||Cell Cycle/Checkpoint
Bioactivity
SYHA1815, an orally active RET inhibitor (IC50=0.9 nmol/L), demonstrates antitumor activity. It exhibits greater selectivity for RET over KDR (IC50=15.9 nmol/L) . SYHA1815 operates by downregulating c-Myc, arresting the G1 cell cycle, and inhibiting RET-driven cell proliferation.
Smiles
Cl.O=C(NC1=CC=C(C(=C1)C(F)(F)F)CN2CCN(C)CC2)C=3C=C(F)C=C(C#CC4=CC=CN=C4N)C3
Molecular Formula
C27H26ClF4N5O
Molecular Weight
547.98
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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